Graves preguntado en Science & MathematicsMedicine · hace 1 mes

Human Dose to animal model?

if the drug Abilify Maintena, an injection, has a prescribed dose of 400mg/mL in humans, what's the human equivalent dose in rats, monkeys, dogs, and rabbits? 

how do you get this number?

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  • Anónimo
    hace 1 mes
    Respuesta preferida

    Well, we need more information about the drug. This is because the way different animals metabolize the same substance can be quite different. Whats more is that some animals might lack the biological pathways that are the mechanism of action of the drug, and thus wouldn't be effected at all.  You can't use a simple dose reduction in this scenario and be at all accurate.

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